1 mg tirzepatide microdose Microdosing 3- Month Micro-dosing Tirzepatide |

29 91 87 91 Annual Report 2025 (January 1 December 31) Adopted at the Annual General Meeting of Shareholders on March 23, 2026

Elevated circulating TSH exacerbates this process by activating toll-like receptor 4 (TLR4), c-Jun N-terminal kinase (JNK), and nuclear factor-B (NF-B) pathways, which inhibit IRS tyrosine phosphorylation and enhance serine phosphorylation, thereby aggravating insulin resistance (50, 51)

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This is particularly important if you have pre-existing kidney conditions, diabetes, or cardiovascular disease, as these factors may influence the safety profile of combining these substances